Kane suffered injuries to both ankles in Thursday’s defeat against Liverpool but Mourinho has other options with striker Carlos Vinicius, Gareth Bale, Son, Erik Lamela and Steven Bergwijn all fit.
The Spurs boss also confirmed defender Joe Rodon will start. Rodon put in an impressive performance against Liverpool, before making a mistake which allowed Sadio Mane to kill the game.
“Next game he plays for sure,” Mourinho said ahead of Brighton. “Against Liverpool he showed good personality, good concentration, was good on the ball."
Scroll down and click through to see how Spurs could line-up for this one.
1. Hugo Lloris
The French goalkeeper sustained a serious elbow injury last time out at the Amex as Tottenham lost 3-0. Will hope for better fortunes on his return today
2. Joe Rodon
Jose Mourinho has already confirmed the Wales international will start at the Amex
3. Eric Dier
The England international is an established member of Mourinho's defensive unit and will be up against Albion's top scorer Neal Maupay
4. Alderweireld
Had a terrible time up against Aaron Connolly last time out at the Amex Stadium. Connolly is fit once again and Alderweireld will hope for better luck against the Ireland international