Head Coach Gabriele Cioffi says Reds will be ready to face a tough start to the new season after the announcement of the 2019-20 fixtures today.
Reds kick off by making the 688-mile round trip to Carlisle on Saturday August 3.
A week later Salford City, newly promoted from the National League, are the first visitors of the season to The People's Pension Stadium.
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They then go to relegated Scunthorpe United on August 17 and visit the other promoted team Leyton Orient a week later, either side of a midweek home date against Crewe.
Cioffi told the club's website said: "It's a tough start for us but I am really looking forward to it.
"You can look at Carlisle in two ways. A long trip to start for sure, but we get it out of the way early.
"Salford at home will be a very interesting fixture. They are an ambitious club and have some amazing owners. Who knows? Perhaps I will meet (Salford co-owner) David Beckham!
"Again there are some long journeys for our supporters but I am sure they will be there as usual to support the team.
"The preparation for the games start now. We are looking forward to August 3 already."